DNAI1

Across TCGA cell cohorts, DNAI1 mutation is significantly associated with the RNA expression of many other genes, with 961 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DNAI1-associated genes across cancer lineages are SLCO1C1, OR2A14, and CYLC1. Each is linked with DNAI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAI1-to-partner and partner-to-DNAI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLCO1C1 grouped by DNAI1-low versus DNAI1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAI1→partner) and Y-score (partner→DNAI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLCO1C1 →	+0.326	+2.128	<.001	.002	3	2
BLOOD_Myeloma	OR2A14 →	+0.033	+4.807	<.001	.006	3	1
CNS	CYLC1 →	+0.006	+5.321	.004	.005	3	1
BREAST	PAGE3 →	+0.042	+4.781	<.001	.003	3	1
BLOOD_Leukemia	TRIM51 →	+0.074	+4.152	<.001	.009	3	1
LARGE_INTESTINE	ANKRD54 →	+0.597	+3.829	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 961 associations by consensus.

SLCO1C1 by DNAI1 expression — LARGE_INTESTINE

Explore this box plot interactively →