DNAI1

Across TCGA pan-cancer cohorts, DNAI1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of DNAI1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where DNAI1 RNA is repressed in tumor relative to normal tissue. In most cancer types DNAI1 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and LUSC are the cancer types where DNAI1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DNAI1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.017	<.001	10	view →
KIRC	Male	II,III,IV	−0.339	<.001	9	view →
LUSC	Female	II,III,IV	−2.268	<.001	8	view →
LUAD	Female	All	−1.539	<.001	8	view →
KIRP	All	II,III,IV	+0.734	.001	8	view →
BRCA	All	III,IV	+0.755	.006	6	view →
PAAD	Female	All	+1.255	.022	2	view →
STAD	All	All	+0.095	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

DNAI1–KICH

Open the KICH breakdown →