DNAH11

Across TCGA patient cohorts, DNAH11 mutation is significantly associated with the RNA expression of many other genes, with 9,724 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAH11-associated genes across cancer lineages are DRG1, TIMM17A, and AIMP2. Each is linked with DNAH11 in more than 6 cancer types. Because this analysis shows association rather than direction, both DNAH11-to-partner and partner-to-DNAH11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DRG1 grouped by DNAH11-low versus DNAH11-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAH11→partner) and Y-score (partner→DNAH11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DRG1 →	+0.351	+2.122	<.001	.002	3	7
BRCA	TIMM17A →	+0.441	+2.064	<.001	.001	3	6
UCEC	AIMP2 →	+0.325	+1.538	<.001	<.001	3	6
UCEC	LRRC59 →	+0.399	+1.134	<.001	<.001	3	6
LUAD	YWHAE →	+0.280	+1.699	.001	<.001	3	6
LUAD	FOXM1 →	+0.814	+1.938	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,724 associations by consensus.

DRG1 by DNAH11 expression — LUAD

Explore this box plot interactively →