DNAH11

Across TCGA pan-cancer cohorts, DNAH11 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated DNAH11 data layer compared with 11 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher DNAH11 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DNAH11 expression acts as an unfavorable survival marker, although some lineages such as SKCM and KIRC show a favorable association.

KIRP, MESO, and BRCA are the cancer types where DNAH11 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	III,IV	0.086	0.583	<.001	125	view →
MESO	DFS	Median	All	0.270	0.454	<.001	87	view →
BRCA	OS	Tertile	II,III,IV	0.928	0.977	<.001	77	view →
LGG	OS	Median	All	0.720	0.899	<.001	54	view →
BLCA	OS	Tertile	III,IV	0.494	0.628	.018	32	view →
THCA	DFS	Median	II,III,IV	0.621	0.813	.008	31	view →
STAD	OS	Quartile	II,III,IV	0.344	0.645	.003	26	view →
SKCM	DFS	Tertile	All	0.706	0.554	.005	24	view →
KICH	DFS	Quartile	III,IV	0.088	1.000	.017	18	view →
READ	DFS	Tertile	III,IV	0.256	0.621	.023	15	view →
COAD	OS	Median	All	0.514	0.707	.019	13	view →
KIRC	DFS	Median	II,III,IV	0.737	0.568	.024	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

DNAH11–KIRP (DFS)

Open the KIRP breakdown →