DNAH11

Across TCGA pan-cancer cohorts, DNAH11 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of DNAH11’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where DNAH11 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DNAH11 is over-expressed in tumor, although a few such as LUSC and THCA show the opposite, repressed pattern.

KIRC, LUSC, and HNSC are the cancer types where DNAH11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DNAH11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	+2.349	<.001	12	view →
LUSC	All	II,III,IV	−0.810	<.001	7	view →
HNSC	Male	II,III,IV	+0.522	.003	5	view →
THCA	Male	III,IV	−0.679	.006	4	view →
BRCA	All	All	+0.250	.001	4	view →
LIHC	All	All	+0.354	<.001	3	view →
STAD	All	All	−0.227	.006	3	view →
CHOL	All	All	+0.794	.007	2	view →
KICH	All	III,IV	−0.197	.016	2	view →
COAD	Female	IV	−0.035	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

DNAH11–KIRC

Open the KIRC breakdown →