DNAH11

Across TCGA patient cohorts, DNAH11 mutation is significantly associated with the total protein of many other genes, with 122 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAH11-associated genes across cancer lineages are ASNS, Cyclin-B1, and 4E-BP1. Each is linked with DNAH11 in more than 7 cancer types. Because this analysis shows association rather than direction, both DNAH11-to-partner and partner-to-DNAH11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by DNAH11-low versus DNAH11-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAH11→partner) and Y-score (partner→DNAH11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ASNS →	+0.359	+2.459	.014	.017	3	8
LUAD	Cyclin-B1 →	+0.684	+3.906	<.001	<.001	3	6
LUAD	4E-BP1 →	+0.333	+2.087	<.001	.004	3	6
COAD	eEF2 →	+0.190	+1.353	.007	.012	3	5
UCEC	FOXO3a_pS318_S321 →	-0.076	-1.238	.006	.001	3	5
LUAD	ACC1 →	+0.294	+2.016	.017	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 122 associations by consensus.

ASNS by DNAH11 expression — LUAD

Explore this box plot interactively →