DNAH1

Across TCGA patient cohorts, DNAH1 mutation is significantly associated with the total protein of many other genes, with 115 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAH1-associated genes across cancer lineages are Caspase-7-cleavedD198, eIF4E, and ERK2. Each is linked with DNAH1 in more than 4 cancer types. Because this analysis shows association rather than direction, both DNAH1-to-partner and partner-to-DNAH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by DNAH1-low versus DNAH1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAH1→partner) and Y-score (partner→DNAH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.202	+1.901	<.001	<.001	3	5
COAD	eIF4E →	+0.163	+1.860	.001	.004	3	4
UCEC	ERK2 →	+0.109	+1.378	.009	.005	3	4
UCEC	TIGAR →	+0.077	+0.826	.020	.010	3	4
UCEC	ATM →	-0.441	-1.940	<.001	<.001	3	3
BRCA	p27_pT198 →	-0.206	-3.164	.010	.020	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 115 associations by consensus.

Caspase-7-cleavedD198 by DNAH1 expression — COAD

Explore this box plot interactively →