DNAH1

Across TCGA pan-cancer cohorts, DNAH1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of DNAH1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where DNAH1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DNAH1 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

KIRC, LUAD, and LUSC are the cancer types where DNAH1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DNAH1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.564	<.001	11	view →
LUAD	All	II,III,IV	−0.749	<.001	8	view →
LUSC	Female	All	−1.260	<.001	7	view →
KICH	Female	All	−0.641	<.001	7	view →
BRCA	All	III,IV	−0.836	<.001	6	view →
COAD	All	IV	+0.784	.010	6	view →
LIHC	Male	All	+0.684	<.001	6	view →
KIRP	All	IV	+0.674	.006	4	view →
THCA	Female	II,III,IV	−0.445	.009	4	view →
HNSC	All	II,III,IV	−0.308	.008	4	view →
STAD	All	II,III,IV	+0.587	.010	3	view →
PRAD	All	All	+0.318	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

DNAH1–KIRC

Open the KIRC breakdown →