DNAH1

Across TCGA pan-cancer cohorts, DNAH1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated DNAH1 data layer compared with 13 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DNAH1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated DNAH1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and BLCA are the cancer types where DNAH1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.776	0.617	<.001	110	view →
SKCM	OS	Tertile	All	0.399	0.237	<.001	76	view →
BLCA	OS	Tertile	All	0.710	0.507	<.001	69	view →
KIRC	DFS	Median	All	0.535	0.690	<.001	68	view →
SCLC	DFS	Quartile	II,III,IV	0.672	0.254	.003	51	view →
STAD	OS	Tertile	II,III,IV	0.744	0.335	.002	36	view →
UCS	DFS	Tertile	IV	0.885	0.250	.024	30	view →
UVM	DFS	Tertile	II,III,IV	0.736	0.347	.004	29	view →
BRCA	OS	Quartile	III,IV	0.805	0.498	.002	26	view →
LUSC	DFS	Median	II,III,IV	0.535	0.677	.008	25	view →
THYM	DFS	Tertile	III,IV	1.000	0.222	.001	20	view →
KIRP	DFS	Quartile	All	0.976	0.873	.012	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

DNAH1–HNSC (DFS)

Open the HNSC breakdown →