DNAH1

Across TCGA cell cohorts, DNAH1 mutation is significantly associated with the RNA expression of many other genes, with 1,218 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DNAH1-associated genes across cancer lineages are HSF2, CCNC, and C12orf29. Each is linked with DNAH1 in more than 3 cancer types. Because this analysis shows association rather than direction, both DNAH1-to-partner and partner-to-DNAH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSF2 grouped by DNAH1-low versus DNAH1-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAH1→partner) and Y-score (partner→DNAH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	HSF2 →	+0.792	+3.372	<.001	.002	3	4
LARGE_INTESTINE	CCNC →	+0.458	+3.321	.002	.002	3	4
LARGE_INTESTINE	C12orf29 →	+0.345	+1.557	.009	.001	3	4
LARGE_INTESTINE	SEPSECS →	+0.503	+1.700	<.001	.005	3	3
LARGE_INTESTINE	CTBS →	+0.670	+1.557	<.001	.001	3	3
BLOOD_Leukemia	TMEM237 →	+0.906	+3.700	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,218 associations by consensus.

HSF2 by DNAH1 expression — BREAST

Explore this box plot interactively →