DNAAF3

Across TCGA patient cohorts, DNAAF3 mutation is significantly associated with the RNA expression of many other genes, with 1,033 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAAF3-associated genes across cancer lineages are PHF5A, NCR1, and KIR3DL1. Each is linked with DNAAF3 in more than 3 cancer types. Because this analysis shows association rather than direction, both DNAAF3-to-partner and partner-to-DNAAF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PHF5A grouped by DNAAF3-low versus DNAAF3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAAF3→partner) and Y-score (partner→DNAAF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PHF5A →	+0.424	+2.641	.006	.005	3	4
UCEC	NCR1 →	+0.534	+1.939	<.001	.009	3	3
COAD	KIR3DL1 →	+0.322	+3.915	<.001	.002	3	3
UCEC	CCL5 →	+1.593	+3.716	<.001	<.001	3	3
UCEC	RPL21P35 →	+0.242	+2.254	<.001	<.001	3	3
UCEC	LINC01871 →	+1.517	+3.923	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,033 associations by consensus.

PHF5A by DNAAF3 expression — UCEC

Explore this box plot interactively →