DNAAF3

Across TCGA pan-cancer cohorts, DNAAF3 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of DNAAF3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where DNAAF3 RNA is repressed in tumor relative to normal tissue. In most cancer types DNAAF3 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and COAD are the cancer types where DNAAF3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DNAAF3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	−0.627	<.001	11	view →
KICH	Female	II,III,IV	−1.985	<.001	10	view →
COAD	All	II,III,IV	+0.687	<.001	10	view →
BLCA	All	All	+0.756	<.001	8	view →
KIRP	All	All	+0.914	<.001	7	view →
THCA	Male	IV	−0.779	<.001	7	view →
BRCA	All	III,IV	+1.446	<.001	6	view →
STAD	All	II,III,IV	+0.989	<.001	6	view →
HNSC	Male	All	+0.692	<.001	6	view →
LUSC	All	All	−0.853	<.001	5	view →
CHOL	Female	All	+0.763	<.001	3	view →
READ	All	III,IV	+0.845	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

DNAAF3–KIRC

Open the KIRC breakdown →