DNAAF3

Across TCGA pan-cancer cohorts, DNAAF3 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated DNAAF3 data layer compared with 5 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher DNAAF3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DNAAF3 expression acts as an unfavorable survival marker, although some lineages such as BRCA and UVM show a favorable association.

KIRC, BRCA, and UVM are the cancer types where DNAAF3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.529	0.743	<.001	117	view →
BRCA	OS	Median	III,IV	0.900	0.762	.001	62	view →
UVM	DFS	Tertile	All	0.917	0.538	.002	50	view →
LGG	DFS	Median	All	0.297	0.458	<.001	48	view →
UCEC	OS	Median	All	0.957	0.895	.001	34	view →
UCS	DFS	Tertile	All	0.222	0.675	.001	32	view →
SCLC	DFS	Tertile	II,III,IV	0.746	0.442	.005	32	view →
KIRP	DFS	Tertile	All	1.000	0.773	.005	24	view →
LIHC	OS	Median	All	0.707	0.849	.003	14	view →
COAD	OS	Median	II,III,IV	0.730	0.836	.012	14	view →
STAD	OS	Quartile	All	0.569	0.346	.019	13	view →
BLCA	DFS	Quartile	All	0.252	0.623	.001	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

DNAAF3–KIRC (OS)

Open the KIRC breakdown →