DNAAF3

Across TCGA cell cohorts, DNAAF3 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible DNAAF3-associated genes across cancer lineages are OR10G2, SIGLEC8, and PRR20B. Each is linked with DNAAF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAAF3-to-partner and partner-to-DNAAF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10G2 grouped by DNAAF3-low versus DNAAF3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAAF3→partner) and Y-score (partner→DNAAF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR10G2 →	+0.074	+4.977	<.001	.007	3	2
LUNG_NSCLC_LUAD	SIGLEC8 →	+0.025	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	PRR20B →	+0.036	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	PRR20A →	+0.036	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	PRR20D →	+0.036	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	PRR20E →	+0.036	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

OR10G2 by DNAAF3 expression — LARGE_INTESTINE

Explore this box plot interactively →