DMXL2

Across TCGA cell cohorts, DMXL2 mutation is significantly associated with the RNA expression of many other genes, with 1,079 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DMXL2-associated genes across cancer lineages are PRPSAP2, C12orf60, and TTC19. Each is linked with DMXL2 in more than 3 cancer types. Because this analysis shows association rather than direction, both DMXL2-to-partner and partner-to-DMXL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRPSAP2 grouped by DMXL2-low versus DMXL2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMXL2→partner) and Y-score (partner→DMXL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PRPSAP2 →	+0.587	+2.614	.002	.003	3	3
LARGE_INTESTINE	C12orf60 →	+0.448	+2.649	.002	.001	3	3
LARGE_INTESTINE	TTC19 →	+0.639	+1.949	<.001	.002	3	3
SKIN	PDZRN4 →	+0.046	+2.509	.001	.005	3	2
SKIN	FZD4 →	-0.765	-3.416	.008	.002	3	2
SKIN	FAM71E2 →	+0.007	+2.345	.002	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,079 associations by consensus.

PRPSAP2 by DMXL2 expression — BLOOD_Leukemia

Explore this box plot interactively →