DMRTB1

Across TCGA cell cohorts, DMRTB1 mutation is significantly associated with the mutation status of many other genes, with 1,802 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DMRTB1-associated genes across cancer lineages are GARRE1, XPO1, and ABCB1. Each is linked with DMRTB1 in more than 3 cancer types. Because this analysis shows association rather than direction, both DMRTB1-to-partner and partner-to-DMRTB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GARRE1 grouped by DMRTB1-low versus DMRTB1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMRTB1→partner) and Y-score (partner→DMRTB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GARRE1 →	+3.050	+3.247	.008	.008	1	4
BLOOD_Leukemia	XPO1 →	+4.050	+3.870	.002	.002	1	3
BLOOD_Leukemia	ABCB1 →	+3.728	+4.078	<.001	<.001	1	3
BLOOD_Lymphoma	GRAP2 →	+5.832	+5.169	<.001	<.001	1	3
UPPER_AERODIGESTIVE_TRACT	ASAP1 →	+5.392	+5.392	.004	.004	1	3
LARGE_INTESTINE	ITPR3 →	+1.584	+2.769	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,802 associations by consensus.

GARRE1 by DMRTB1 expression — BLOOD_Leukemia

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