DMRTB1

Across TCGA pan-cancer cohorts, DMRTB1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of DMRTB1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where DMRTB1 RNA is repressed in tumor relative to normal tissue. In most cancer types DMRTB1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

THCA, UCEC, and LUAD are the cancer types where DMRTB1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DMRTB1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.549	.019	3	view →
UCEC	All	All	+0.091	.026	2	view →
LUAD	Female	All	+0.011	.037	1	view →
LIHC	Male	All	+0.011	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

DMRTB1–THCA

Open the THCA breakdown →