DLL4

Across TCGA patient cohorts, DLL4 mutation is significantly associated with the RNA expression of many other genes, with 1,754 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DLL4-associated genes across cancer lineages are MIR122HG, VN1R69P, and HEXIM2. Each is linked with DLL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DLL4-to-partner and partner-to-DLL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR122HG grouped by DLL4-low versus DLL4-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLL4→partner) and Y-score (partner→DLL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR122HG →	+0.022	+3.854	.008	.008	3	2
LUAD	VN1R69P →	+0.112	+6.315	<.001	.001	3	2
UCEC	HEXIM2 →	+0.366	+2.070	.003	.001	3	2
SKCM	TSSK6 →	+0.413	+2.093	.002	.003	3	2
SKCM	MIR515-2 →	+0.072	+3.634	<.001	.001	3	2
SKCM	TRMT2A →	+0.437	+2.591	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,754 associations by consensus.

MIR122HG by DLL4 expression — CESC

Explore this box plot interactively →