DLL4

Across TCGA pan-cancer cohorts, DLL4 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated DLL4 data layer compared with 5 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher DLL4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DLL4 expression acts as an unfavorable survival marker, although some lineages such as KIRC and HNSC show a favorable association.

UVM, KIRP, and KIRC are the cancer types where DLL4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.373	0.880	<.001	145	view →
KIRP	DFS	Median	II,III,IV	0.161	0.928	<.001	98	view →
KIRC	OS	Tertile	All	0.720	0.567	.002	49	view →
CESC	OS	Quartile	All	0.434	0.782	<.001	48	view →
LUSC	DFS	Quartile	All	0.534	0.739	<.001	37	view →
MESO	OS	Median	All	0.264	0.700	.003	31	view →
BRCA	DFS	Quartile	All	0.456	0.598	.007	26	view →
HNSC	DFS	Quartile	IV	0.656	0.462	.008	25	view →
THCA	OS	Tertile	II,III,IV	0.773	0.948	.009	23	view →
SCLC	OS	Median	IV	0.219	0.729	.003	21	view →
PAAD	OS	Quartile	All	0.485	0.197	.011	20	view →
LAML	DFS	Quartile	All	0.572	0.195	.003	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

DLL4–UVM (OS)

Open the UVM breakdown →