DLK2

Across TCGA cell cohorts, DLK2 mutation is significantly associated with the mutation status of many other genes, with 1,032 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DLK2-associated genes across cancer lineages are SPTBN1, GAREM2, and ANKZF1. Each is linked with DLK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both DLK2-to-partner and partner-to-DLK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPTBN1 grouped by DLK2-low versus DLK2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLK2→partner) and Y-score (partner→DLK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SPTBN1 →	+4.044	+5.000	.008	.008	1	3
BLOOD_Leukemia	GAREM2 →	+4.321	+5.285	.005	.005	1	3
BLOOD_Leukemia	ANKZF1 →	+6.321	+6.321	.001	.001	1	3
BLOOD_Leukemia	FMO5 →	+4.000	+5.050	.008	.008	1	3
LARGE_INTESTINE	PPEF1 →	+3.672	+4.799	.002	.002	1	2
LARGE_INTESTINE	LAMB1 →	+2.865	+4.217	.007	.007	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,032 associations by consensus.

SPTBN1 by DLK2 expression — CNS

Explore this box plot interactively →