DLG5

Across TCGA patient cohorts, DLG5 mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DLG5-associated genes across cancer lineages are 4E-BP1, Cyclin-B1, and Rad50. Each is linked with DLG5 in more than 3 cancer types. Because this analysis shows association rather than direction, both DLG5-to-partner and partner-to-DLG5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by DLG5-low versus DLG5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLG5→partner) and Y-score (partner→DLG5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.283	+2.415	<.001	.002	3	4
UCEC	Cyclin-B1 →	+0.720	+1.784	<.001	<.001	3	4
COAD	Rad50 →	-0.364	-2.991	.003	.036	3	3
UCEC	eIF4E →	+0.179	+2.523	.002	<.001	3	3
SKCM	ACC1 →	+0.331	+2.919	.002	<.001	3	3
UCEC	Shc_pY317 →	-0.187	-2.662	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

4E-BP1 by DLG5 expression — UCEC

Explore this box plot interactively →