DLG5

Across TCGA pan-cancer cohorts, DLG5 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated DLG5 data layer compared with 11 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DLG5 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated DLG5 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

HNSC, LIHC, and BRCA are the cancer types where DLG5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.742	0.515	<.001	68	view →
LIHC	DFS	Tertile	All	0.446	0.624	<.001	40	view →
BRCA	OS	Quartile	III,IV	0.925	0.722	.001	38	view →
LGG	OS	Median	All	0.511	0.367	<.001	36	view →
UCS	DFS	Tertile	IV	0.975	0.401	.024	30	view →
COAD	DFS	Quartile	II,III,IV	0.589	0.757	.011	27	view →
ESCA	OS	Median	II,III,IV	0.645	0.396	.005	23	view →
UVM	DFS	Median	III,IV	0.220	0.664	.020	18	view →
BLCA	DFS	Median	All	0.190	0.458	.001	14	view →
MESO	DFS	Median	All	0.268	0.582	.009	14	view →
DLBC	DFS	Median	IV	0.128	1.000	.017	13	view →
ACC	OS	Tertile	IV	0.792	0.299	.006	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

DLG5–HNSC (DFS)

Open the HNSC breakdown →