DLG5

Across TCGA pan-cancer cohorts, DLG5 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of DLG5’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where DLG5 RNA is repressed in tumor relative to normal tissue. In most cancer types DLG5 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

THCA, LUAD, and LIHC are the cancer types where DLG5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DLG5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−1.174	<.001	10	view →
LUAD	Male	II,III,IV	+1.518	<.001	9	view →
LIHC	Male	II,III,IV	+1.493	<.001	9	view →
COAD	Female	All	+0.647	<.001	9	view →
LUSC	Male	II,III,IV	+1.706	<.001	8	view →
HNSC	All	All	+0.743	<.001	7	view →
KIRP	All	II,III,IV	+0.716	.005	7	view →
CHOL	All	All	+2.427	<.001	5	view →
BRCA	All	II,III,IV	+0.500	.001	4	view →
PAAD	All	All	+1.235	.037	2	view →
KIRC	All	All	+0.281	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

DLG5–THCA

Open the THCA breakdown →