DLG5

Across TCGA cell cohorts, DLG5 mutation is significantly associated with the RNA expression of many other genes, with 799 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DLG5-associated genes across cancer lineages are BUB3, TBPL2, and RIC8B. Each is linked with DLG5 in more than 2 cancer types. Because this analysis shows association rather than direction, both DLG5-to-partner and partner-to-DLG5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BUB3 grouped by DLG5-low versus DLG5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLG5→partner) and Y-score (partner→DLG5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BUB3 →	+0.377	+2.526	.004	.002	3	3
SKIN	TBPL2 →	+0.031	+2.777	<.001	.004	3	2
BLOOD_Leukemia	RIC8B →	+0.632	+3.228	.002	.004	3	2
BLOOD_Leukemia	TTK →	+0.577	+3.503	.009	.001	3	2
BLOOD_Leukemia	HELLS →	+0.683	+2.145	.002	.006	3	2
LARGE_INTESTINE	SMAD9 →	+0.872	+2.782	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 799 associations by consensus.

BUB3 by DLG5 expression — LARGE_INTESTINE

Explore this box plot interactively →