DLG4

Across TCGA patient cohorts, DLG4 mutation is significantly associated with the RNA expression of many other genes, with 3,777 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DLG4-associated genes across cancer lineages are KIF9-AS1, HDDC2, and CCDC62. Each is linked with DLG4 in more than 2 cancer types. Because this analysis shows association rather than direction, both DLG4-to-partner and partner-to-DLG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIF9-AS1 grouped by DLG4-low versus DLG4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLG4→partner) and Y-score (partner→DLG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KIF9-AS1 →	+0.368	+1.962	<.001	<.001	3	3
UCEC	HDDC2 →	+0.274	+1.549	.004	.002	3	3
UCEC	CCDC62 →	+0.124	+1.649	.003	.002	3	3
UCEC	TACC3 →	+0.476	+3.329	.003	<.001	3	3
SKCM	RAPSN →	+0.421	+2.366	<.001	.003	3	3
BLCA	OR2Q1P →	+0.026	+4.229	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,777 associations by consensus.

KIF9-AS1 by DLG4 expression — UCEC

Explore this box plot interactively →