DLG4

Across TCGA pan-cancer cohorts, DLG4 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated DLG4 data layer compared with 4 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher DLG4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DLG4 expression acts as an unfavorable survival marker, although some lineages such as SKCM and PAAD show a favorable association.

UVM, BLCA, and SKCM are the cancer types where DLG4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.331	0.631	<.001	77	view →
BLCA	OS	Quartile	III,IV	0.248	0.540	.002	52	view →
SKCM	OS	Quartile	II,III,IV	0.407	0.182	<.001	50	view →
MESO	OS	Median	All	0.433	0.648	.001	45	view →
LUSC	DFS	Tertile	III,IV	0.137	0.832	<.001	43	view →
KIRC	DFS	Median	II,III,IV	0.415	0.655	.001	42	view →
ACC	DFS	Quartile	II,III,IV	0.133	0.720	<.001	36	view →
PAAD	DFS	Tertile	All	0.392	0.176	.004	29	view →
COAD	DFS	Median	All	0.370	0.603	.004	14	view →
LUAD	OS	Median	All	0.853	0.771	.003	13	view →
KIRP	DFS	Quartile	III,IV	0.087	1.000	.008	12	view →
BRCA	OS	Tertile	III,IV	0.725	0.478	.002	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

DLG4–UVM (DFS)

Open the UVM breakdown →