DLG3

Across TCGA patient cohorts, DLG3 mutation is significantly associated with the RNA expression of many other genes, with 5,202 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DLG3-associated genes across cancer lineages are PGAP2, SETD9, and GMEB1. Each is linked with DLG3 in more than 2 cancer types. Because this analysis shows association rather than direction, both DLG3-to-partner and partner-to-DLG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PGAP2 grouped by DLG3-low versus DLG3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLG3→partner) and Y-score (partner→DLG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PGAP2 →	+0.329	+1.496	<.001	<.001	3	3
UCEC	SETD9 →	+0.278	+1.257	.007	.009	3	3
UCEC	GMEB1 →	+0.294	+1.485	<.001	<.001	3	3
UCEC	METTL17 →	+0.250	+1.357	.001	<.001	3	3
UCEC	NUDCD2 →	+0.365	+1.506	<.001	<.001	3	3
UCEC	DBNDD1 →	+0.354	+1.115	.007	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,202 associations by consensus.

PGAP2 by DLG3 expression — UCEC

Explore this box plot interactively →