DLD

Across TCGA patient cohorts, DLD mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DLD-associated genes across cancer lineages are Ku80, p38-MAPK_pT180_Y182, and ETS-1. Each is linked with DLD in more than 1 cancer types. Because this analysis shows association rather than direction, both DLD-to-partner and partner-to-DLD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by DLD-low versus DLD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLD→partner) and Y-score (partner→DLD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.256	+3.183	.049	.010	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.529	-3.156	.032	.020	3	1
UCEC	ETS-1 →	-0.390	-3.169	.025	.020	2	1
UCEC	FoxM1 →	+0.392	+2.817	.005	.036	2	1
UCEC	MEK1 →	+0.572	+3.169	.004	.020	2	1
UCEC	PDCD4 →	-0.680	-3.169	.008	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Ku80 by DLD expression — UCEC

Explore this box plot interactively →