DLD

Across TCGA pan-cancer cohorts, DLD RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated DLD data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher DLD RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated DLD expression acts as an unfavorable survival marker, although some lineages such as KIRC and KIRP show a favorable association.

KIRC, UVM, and KICH are the cancer types where DLD RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.724	0.523	<.001	68	view →
UVM	DFS	Quartile	II,III,IV	0.273	0.781	<.001	51	view →
KICH	OS	Quartile	All	0.495	0.938	.004	43	view →
LUAD	DFS	Median	All	0.738	0.839	.002	40	view →
LGG	OS	Tertile	All	0.733	0.886	<.001	32	view →
KIRP	DFS	Median	All	0.910	0.801	.004	28	view →
LUSC	OS	Tertile	II,III,IV	0.675	0.517	.013	21	view →
ACC	DFS	Median	III,IV	0.569	0.124	.004	19	view →
THCA	OS	Median	All	0.963	1.000	.014	16	view →
BRCA	OS	Quartile	II,III,IV	0.647	0.713	.012	14	view →
LIHC	DFS	Median	III,IV	0.100	0.277	.017	13	view →
READ	OS	Quartile	II,III,IV	1.000	0.804	.021	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

DLD–KIRC (DFS)

Open the KIRC breakdown →