DLD

Across TCGA pan-cancer cohorts, DLD RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of DLD’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where DLD RNA is repressed in tumor relative to normal tissue. In most cancer types DLD is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and LIHC are the cancer types where DLD tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DLD RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.719	<.001	11	view →
THCA	Male	III,IV	−1.025	<.001	9	view →
LIHC	All	All	+0.522	<.001	7	view →
COAD	Male	All	−0.296	<.001	6	view →
LUSC	Male	II,III,IV	+0.611	<.001	5	view →
LUAD	Male	All	+0.364	<.001	4	view →
BRCA	All	All	−0.140	.036	2	view →
CHOL	All	All	+0.555	.031	1	view →
BLCA	Male	III,IV	−0.474	.034	1	view →
ESCA	Male	All	+0.418	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

DLD–KIRC

Open the KIRC breakdown →