DLD

Across TCGA cell cohorts, DLD RNA expression is significantly associated with the go_rna of many other GO terms, with 3,342 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DLD-associated GO terms across cancer lineages are Positive regulation of isotype switching to IgG isotypes, Mitochondrial RNA metabolic process, and Positive regulation of cell cycle phase transition. Each is linked with DLD in more than 15 cancer types. Because this analysis shows association rather than direction, both DLD-to-partner and partner-to-DLD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of isotype switching to IgG isotypes grouped by DLD-low versus DLD-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DLD→partner) and Y-score (partner→DLD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Positive regulation of isotype switching to IgG isotypes →	+0.131	+0.991	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Mitochondrial RNA metabolic process →	+0.085	+1.358	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Positive regulation of cell cycle phase transition →	+0.102	+1.489	.001	.003	3	11
BLOOD_Myeloma	DNA replication initiation →	+0.145	+0.792	<.001	<.001	3	10
SOFT_TISSUE	Lagging strand elongation →	+0.129	+0.923	<.001	.003	3	10
UPPER_AERODIGESTIVE_TRACT	Protein localization to kinetochore →	+0.166	+1.700	.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,342 associations by consensus.

Positive regulation of isotype switching to IgG isotypes by DLD expression — SKIN

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