DKK4

Across TCGA patient cohorts, DKK4 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,824 significant associations in total. TGCT shows the largest number of these associations.

The most reproducible DKK4-associated GO terms across cancer lineages are Regulation of nucleotide-excision repair, Regulation of protein complex stability, and Regulation of animal organ morphogenesis. Each is linked with DKK4 in more than 10 cancer types. Because this analysis shows association rather than direction, both DKK4-to-partner and partner-to-DKK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of nucleotide-excision repair grouped by DKK4-low versus DKK4-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DKK4→partner) and Y-score (partner→DKK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Regulation of nucleotide-excision repair →	+0.040	+0.602	<.001	.001	3	10
TGCT	Regulation of protein complex stability →	+0.070	+0.670	<.001	<.001	3	10
TGCT	Regulation of animal organ morphogenesis →	+0.071	+1.231	<.001	<.001	3	10
TGCT	Bud elongation involved in lung branching →	+0.107	+0.834	<.001	<.001	3	10
KIRP	Negative regulation of RNA splicing →	+0.034	+0.283	<.001	.001	3	9
UVM	Lipoprotein biosynthetic process →	+0.037	+0.091	<.001	<.001	1	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,824 associations by consensus.

Regulation of nucleotide-excision repair by DKK4 expression — STAD

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