DKK4

Across TCGA patient cohorts, DKK4 protein abundance is significantly associated with the RNA expression of many other genes, with 3,407 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DKK4-associated genes across cancer lineages are GAPDHP27, TPH1, and CRYBA4. Each is linked with DKK4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DKK4-to-partner and partner-to-DKK4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DKK4 versus GAPDHP27 in UCEC, with a Pearson correlation of 0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DKK4→partner) and Y-score (partner→DKK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDHP27 →	+0.401	+1.526	.007	.002	3	2
BRCA	TPH1 →	+3.045	+2.333	.002	.009	3	2
UCEC	CRYBA4 →	+0.761	+1.969	<.001	<.001	3	2
OV	COX6C →	-1.343	-1.109	.001	.002	2	2
OV	NPM1P42 →	-0.326	-1.017	<.001	.001	2	2
UCEC	SEZ6L →	+1.597	+2.162	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,407 associations by consensus.

DKK4 vs GAPDHP27 — UCEC

Explore this scatter interactively →