DKK4

Across TCGA cell cohorts, DKK4 RNA expression is significantly associated with the go_rna of many other GO terms, with 770 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible DKK4-associated GO terms across cancer lineages are Cellular response to ketone, Regulation of endoplasmic reticulum tubular network organization, and Transport of virus. Each is linked with DKK4 in more than 4 cancer types. Because this analysis shows association rather than direction, both DKK4-to-partner and partner-to-DKK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to ketone grouped by DKK4-low versus DKK4-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DKK4→partner) and Y-score (partner→DKK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Cellular response to ketone →	+0.066	+1.183	<.001	.004	3	4
PANCREAS	Regulation of endoplasmic reticulum tubular network organization →	-0.090	-0.655	<.001	.002	3	4
LUNG_NSCLC_LUAD	Transport of virus →	-0.091	-0.085	.004	.001	3	4
LUNG_NSCLC_LUAD	Intracellular transport of virus →	-0.091	-0.085	.004	.001	3	4
BLOOD_Myeloma	Response to cell cycle checkpoint signaling →	-0.082	-0.021	.002	.005	2	4
BLOOD_Myeloma	Response to DNA integrity checkpoint signaling →	-0.082	-0.021	.002	.005	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 770 associations by consensus.

Cellular response to ketone by DKK4 expression — STOMACH

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