DKK4

Across TCGA cell cohorts, DKK4 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible DKK4-associated genes across cancer lineages are RLN3, ODF4, and MAGEB4. Each is linked with DKK4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DKK4-to-partner and partner-to-DKK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RLN3 grouped by DKK4-low versus DKK4-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DKK4→partner) and Y-score (partner→DKK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RLN3 →	+0.070	+4.977	<.001	.007	3	1
SKIN	ODF4 →	+0.038	+4.977	<.001	.007	3	1
LARGE_INTESTINE	MAGEB4 →	+0.012	+5.415	.009	.004	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

RLN3 by DKK4 expression — SKIN

Explore this box plot interactively →