DISP2

Across TCGA patient cohorts, DISP2 mutation is significantly associated with the RNA expression of many other genes, with 1,992 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DISP2-associated genes across cancer lineages are GLOD4, MIR4539, and SFPQP1. Each is linked with DISP2 in more than 3 cancer types. Because this analysis shows association rather than direction, both DISP2-to-partner and partner-to-DISP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GLOD4 grouped by DISP2-low versus DISP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DISP2→partner) and Y-score (partner→DISP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GLOD4 →	+0.398	+2.917	.001	<.001	3	4
CESC	MIR4539 →	+1.077	+3.772	.003	.003	3	4
SKCM	SFPQP1 →	+0.033	+2.339	<.001	<.001	3	4
UCEC	SPATA5L1 →	+0.406	+2.069	.001	<.001	3	3
UCEC	AP3D1 →	+0.515	+3.279	<.001	<.001	3	3
OV	TUBB4BP5 →	+0.081	+5.333	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,992 associations by consensus.

GLOD4 by DISP2 expression — UCEC

Explore this box plot interactively →