DIS3L

Across TCGA patient cohorts, DIS3L protein abundance is significantly associated with the RNA expression of many other genes, with 4,369 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible DIS3L-associated genes across cancer lineages are PNRC1, LINC02328, and ALG1. Each is linked with DIS3L in more than 2 cancer types. Because this analysis shows association rather than direction, both DIS3L-to-partner and partner-to-DIS3L results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DIS3L versus PNRC1 in BRCA, with a Pearson correlation of 0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DIS3L→partner) and Y-score (partner→DIS3L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PNRC1 →	+0.553	+0.305	.002	<.001	3	3
LSCC	LINC02328 →	+0.407	+0.144	.003	.004	3	3
OV	ALG1 →	-0.479	-0.333	.002	.003	3	3
OV	NUDT16L1 →	-0.571	-0.300	.003	.006	3	3
HNSC	MTR →	+0.439	+0.266	<.001	<.001	3	2
PDAC	KLF12 →	+0.689	+0.425	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,369 associations by consensus.

DIS3L vs PNRC1 — BRCA

Explore this scatter interactively →