DIS3L

Across TCGA cell cohorts, DIS3L RNA expression is significantly associated with the go_rna of many other GO terms, with 4,574 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DIS3L-associated GO terms across cancer lineages are Positive regulation of cytokinesis, Protein polymerization, and DNA strand elongation involved in DNA replication. Each is linked with DIS3L in more than 13 cancer types. Because this analysis shows association rather than direction, both DIS3L-to-partner and partner-to-DIS3L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cytokinesis grouped by DIS3L-low versus DIS3L-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DIS3L→partner) and Y-score (partner→DIS3L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Positive regulation of cytokinesis →	+0.146	+1.113	<.001	<.001	3	14
SOFT_TISSUE	Protein polymerization →	+0.048	+0.586	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	DNA strand elongation involved in DNA replication →	+0.182	+1.266	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Regulation of cell cycle checkpoint →	+0.092	+0.950	.001	<.001	3	13
PANCREAS	Positive regulation of mitotic cytokinesis →	+0.174	+1.033	<.001	<.001	3	13
BREAST	Regulation of mitotic cytokinesis →	+0.134	+0.712	.002	.003	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,574 associations by consensus.

Positive regulation of cytokinesis by DIS3L expression — PANCREAS

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