DIRAS1

Across TCGA patient cohorts, DIRAS1 protein abundance is significantly associated with the RNA expression of many other genes, with 4,979 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DIRAS1-associated genes across cancer lineages are RNU6-884P, KCNH1-IT1, and DUXAP2. Each is linked with DIRAS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DIRAS1-to-partner and partner-to-DIRAS1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DIRAS1 versus RNU6-884P in UCEC, with a Pearson correlation of 0.87.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DIRAS1→partner) and Y-score (partner→DIRAS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-884P →	+3.690	+0.718	<.001	.009	3	1
UCEC	KCNH1-IT1 →	+0.945	+0.657	.007	.007	3	1
UCEC	DUXAP2 →	+0.490	+0.657	.003	.007	3	1
UCEC	LINC02673 →	+0.224	+0.657	.004	.007	3	1
UCEC	FRG2KP →	+0.260	+0.657	.005	.007	3	1
UCEC	RPL17P3 →	+0.794	+0.657	.008	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,979 associations by consensus.

DIRAS1 vs RNU6-884P — UCEC

Explore this scatter interactively →