DIAPH1

Across TCGA patient cohorts, DIAPH1 mutation is significantly associated with the RNA expression of many other genes, with 5,142 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DIAPH1-associated genes across cancer lineages are MFSD12, PRELID3BP2, and GSTA9P. Each is linked with DIAPH1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DIAPH1-to-partner and partner-to-DIAPH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MFSD12 grouped by DIAPH1-low versus DIAPH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DIAPH1→partner) and Y-score (partner→DIAPH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MFSD12 →	+0.280	+1.354	.007	.001	3	3
HNSC	PRELID3BP2 →	+0.105	+5.626	<.001	.001	3	3
UCEC	GSTA9P →	+0.794	+1.321	.003	.002	3	3
UCEC	GRHPR →	+0.346	+3.321	<.001	<.001	3	3
UCEC	COX7C →	+0.433	+1.788	<.001	<.001	3	3
LGG	USP9YP6 →	+0.044	+7.977	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,142 associations by consensus.

MFSD12 by DIAPH1 expression — UCEC

Explore this box plot interactively →