DIAPH1

Across TCGA pan-cancer cohorts, DIAPH1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of DIAPH1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where DIAPH1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DIAPH1 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.

COAD, KIRC, and BLCA are the cancer types where DIAPH1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DIAPH1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	II,III,IV	+0.540	<.001	11	view →
KIRC	Female	All	+0.593	<.001	8	view →
BLCA	Male	III,IV	+1.132	.001	6	view →
BRCA	All	II,III,IV	+0.369	<.001	6	view →
STAD	All	II,III,IV	+0.870	.003	5	view →
LUSC	All	All	−0.331	<.001	5	view →
UCEC	All	III,IV	+0.964	.011	4	view →
LIHC	Male	All	+0.431	.003	4	view →
KIRP	All	II,III,IV	+0.356	.026	3	view →
READ	All	III,IV	+0.960	.003	2	view →
PRAD	All	All	+0.517	<.001	2	view →
HNSC	All	All	+0.314	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

DIAPH1–COAD

Open the COAD breakdown →