DIAPH1-AS1

Across TCGA pan-cancer cohorts, DIAPH1-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated DIAPH1-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DIAPH1-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DIAPH1-AS1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and LAML show a favorable association.

HNSC, BLCA, and LAML are the cancer types where DIAPH1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	III,IV	0.361	0.639	.001	34	view →
BLCA	OS	Median	III,IV	0.710	0.603	.007	32	view →
LAML	DFS	Median	All	0.750	0.411	<.001	30	view →
LIHC	OS	Tertile	All	0.790	0.643	.007	25	view →
TGCT	DFS	Tertile	All	0.499	0.769	.019	20	view →
MESO	DFS	Median	All	0.301	0.192	.024	19	view →
THCA	OS	Median	IV	0.571	0.939	.004	19	view →
ACC	OS	Tertile	III,IV	0.919	0.434	.008	11	view →
UCEC	OS	Tertile	II,III,IV	0.736	0.314	.029	10	view →
LUSC	DFS	Tertile	All	0.609	0.737	.009	9	view →
DLBC	OS	Tertile	II,III,IV	0.547	1.000	.042	9	view →
SKCM	OS	Tertile	III,IV	0.265	0.441	.020	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

DIAPH1-AS1–HNSC (OS)

Open the HNSC breakdown →