DIAPH1-AS1

Across TCGA pan-cancer cohorts, DIAPH1-AS1 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of DIAPH1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where DIAPH1-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types DIAPH1-AS1 is over-expressed in tumor, although a few such as LUSC and STAD show the opposite, repressed pattern.

LUSC, KIRC, and STAD are the cancer types where DIAPH1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DIAPH1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	All	−0.058	<.001	4	view →
KIRC	All	All	+0.014	.011	4	view →
STAD	Male	IV	−0.185	<.001	2	view →
STAD	All	II,III,IV	+0.079	.043	2	view →
BRCA	All	III,IV	−0.044	.004	2	view →
THCA	All	All	−0.021	.006	2	view →
LUAD	Male	III,IV	−0.061	.017	1	view →
COAD	All	III,IV	−0.030	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 7 lineages.

DIAPH1-AS1–LUSC

Open the LUSC breakdown →