Q-omics provides the consensus-scored DIAPH1-AS1 profile across patient tissues and cancer cell-line models. DIAPH1-AS1 expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, DIAPH1-AS1 is differentially expressed in 7, with the highest sampling consensus in LUSC. Additionally, DIAPH1-AS1 RNA expression shows 9,068 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight HNSC, LUSC, and THYM as cancer lineages where DIAPH1-AS1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for DIAPH1-AS1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes DIAPH1-AS1 survival associations across molecular data types. DIAPH1-AS1 RNA expression shows survival associations in the most cancer types (21). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible DIAPH1-AS1 RNA expression–survival associations across cancer types. High DIAPH1-AS1 expression shows unfavorable associations in HNSC and TGCT, but favorable associations in BLCA, LAML, LIHC and MESO. The HNSC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .001). Together, the overview and detailed table identify HNSC as the clearest survival context for DIAPH1-AS1 RNA expression.
This table summarizes DIAPH1-AS1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 7. The strongest signals are observed in LUSC for RNA.
This table ranks reproducible tumor–normal expression differences for DIAPH1-AS1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. DIAPH1-AS1 shows lower tumor expression in LUSC, STAD, BRCA and THCA and higher tumor expression in KIRC and STAD. The LUSC box plot shows higher DIAPH1-AS1 RNA expression in normal versus tumor tissue (log2 FC = −0.058, t-test p < 0.001).
This table shows molecular features associated with DIAPH1-AS1 in patient tissues and cancer cell lines. In patient samples, DIAPH1-AS1 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set.
