DHX58

Across TCGA patient cohorts, DHX58 mutation is significantly associated with the RNA expression of many other genes, with 1,394 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHX58-associated genes across cancer lineages are RN7SL248P, HSBP1P1, and RNA5SP148. Each is linked with DHX58 in more than 1 cancer types. Because this analysis shows association rather than direction, both DHX58-to-partner and partner-to-DHX58 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by DHX58-low versus DHX58-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHX58→partner) and Y-score (partner→DHX58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.096	+3.796	<.001	<.001	3	2
SKCM	HSBP1P1 →	+0.219	+3.915	.001	.002	3	2
BRCA	RNA5SP148 →	+0.790	+7.731	<.001	.009	3	2
UCEC	EME1 →	+0.538	+2.627	.002	.005	3	2
UCEC	SRP68 →	+0.404	+2.346	.001	.003	3	2
UCEC	ZBTB8OS →	+0.320	+3.922	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,394 associations by consensus.

RN7SL248P by DHX58 expression — UCEC

Explore this box plot interactively →