DHRS7

Across TCGA patient cohorts, DHRS7 mutation is significantly associated with the RNA expression of many other genes, with 1,912 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHRS7-associated genes across cancer lineages are SEPTIN14P19, LIN28AP2, and IGHD1-20. Each is linked with DHRS7 in more than 1 cancer types. Because this analysis shows association rather than direction, both DHRS7-to-partner and partner-to-DHRS7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEPTIN14P19 grouped by DHRS7-low versus DHRS7-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHRS7→partner) and Y-score (partner→DHRS7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SEPTIN14P19 →	+0.059	+5.822	<.001	.003	3	2
COAD	LIN28AP2 →	+0.173	+5.251	<.001	.003	3	2
HNSC	IGHD1-20 →	+1.400	+5.015	<.001	.009	3	2
BRCA	RNA5SP34 →	+0.175	+7.471	.009	.008	3	2
SKCM	TUBBP11 →	+0.193	+4.979	.002	.009	3	2
UCEC	HMGB3P3 →	+0.195	+2.320	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,912 associations by consensus.

SEPTIN14P19 by DHRS7 expression — HNSC

Explore this box plot interactively →