DHRS7

Across TCGA pan-cancer cohorts, DHRS7 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated DHRS7 data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DHRS7 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DHRS7 expression acts as an unfavorable survival marker, although some lineages such as BRCA and KIRC show a favorable association.

HNSC, BRCA, and KIRC are the cancer types where DHRS7 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.590	0.733	<.001	197	view →
BRCA	OS	Median	II,III,IV	0.946	0.879	<.001	88	view →
KIRC	DFS	Median	All	0.701	0.545	<.001	86	view →
UVM	DFS	Quartile	All	0.285	0.857	<.001	59	view →
STAD	DFS	Quartile	All	0.203	0.634	.003	57	view →
MESO	OS	Tertile	All	0.748	0.309	.001	41	view →
LGG	OS	Quartile	All	0.831	0.944	<.001	22	view →
THCA	DFS	Median	All	0.901	0.786	.009	21	view →
LAML	DFS	Quartile	All	0.766	0.454	.024	18	view →
CESC	DFS	Quartile	All	0.624	0.797	.007	18	view →
READ	OS	Quartile	All	0.453	1.000	.005	14	view →
SKCM	OS	Tertile	IV	0.472	0.857	.005	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

DHRS7–HNSC (OS)

Open the HNSC breakdown →