DHRS7

Across TCGA pan-cancer cohorts, DHRS7 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of DHRS7’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where DHRS7 RNA is repressed in tumor relative to normal tissue. In most cancer types DHRS7 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and KICH are the cancer types where DHRS7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DHRS7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−0.768	<.001	12	view →
THCA	Male	IV	−1.370	<.001	11	view →
KICH	Male	All	+1.605	<.001	7	view →
HNSC	Female	All	+0.867	<.001	6	view →
LUSC	All	III,IV	−0.846	<.001	6	view →
LIHC	All	All	+0.692	<.001	6	view →
BRCA	All	All	+0.301	<.001	4	view →
STAD	All	All	−0.474	.014	2	view →
PRAD	All	All	+0.397	.024	2	view →
KIRP	All	II,III,IV	+0.393	.026	2	view →
READ	Female	All	−0.695	.021	1	view →
COAD	Female	IV	−0.400	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

DHRS7–KIRC

Open the KIRC breakdown →