DHRS7

Across TCGA patient cohorts, DHRS7 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHRS7-associated genes across cancer lineages are MEK1, EGFR_pY1068, and eIF4E. Each is linked with DHRS7 in more than 1 cancer types. Because this analysis shows association rather than direction, both DHRS7-to-partner and partner-to-DHRS7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by DHRS7-low versus DHRS7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHRS7→partner) and Y-score (partner→DHRS7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.433	+2.584	.005	.010	3	2
UCEC	EGFR_pY1068 →	-0.337	-2.906	.001	.001	3	1
UCEC	eIF4E →	+0.216	+2.222	.015	.011	3	1
UCEC	A-Raf_pS299 →	-0.154	-3.459	.002	.005	3	1
UCEC	Heregulin →	-0.130	-2.986	.012	.035	3	1
UCEC	IRS1 →	-0.221	-2.999	.012	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

MEK1 by DHRS7 expression — UCEC

Explore this box plot interactively →