Across TCGA patient cohorts, DHFR protein abundance is significantly associated with the RNA expression of many other genes, with 13,866 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DHFR-associated genes across cancer lineages are GINS1, MCM4, and LMNB1. Each is linked with DHFR in more than 9 cancer types. Because this analysis shows association rather than direction, both DHFR-to-partner and partner-to-DHFR results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHFR→partner) and Y-score (partner→DHFR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GINS1 →	+0.872	+0.725	<.001	<.001	3	10
OV	MCM4 →	+0.907	+0.597	<.001	<.001	3	10
UCEC	LMNB1 →	+1.079	+0.644	<.001	<.001	3	10
GBM	GINS2 →	+0.968	+0.748	<.001	<.001	3	10
LSCC	BRCA2 →	+0.821	+0.533	<.001	<.001	3	10
LUAD	PLK4 →	+0.829	+0.587	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,866 associations by consensus.

Exploration

DHFR survival (RNA) · tumor vs normal (RNA) · all DHFR data types